Opportunities in IgA Nephropathy Research: Exploring the 4 Hit Process

(StatePoint) IgA nephropathy is a progressive, autoimmune, chronic disease that predominantly affects adults between the ages of 20 and 40, with an annual global incidence of 2.5 cases per 100,000 people. Despite its prevalence, IgA nephropathy remains a challenging disease to manage and treat.

The condition is characterized by the accumulation of immune complexes containing Gd-IgA1 in the kidneys. Over time, IgA nephropathy leads to kidney injury and can progress to kidney failure, requiring dialysis and/or kidney transplantation.

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