CHICAGO, May 31, 2026 /PRNewswire/ --Â Oricell Therapeutics, a clinical-stage biotech company pioneering cancer immunotherapy, today announced that its lead asset, Ori-C101, a GPC3-targeted CAR-T therapy, achieved a 66.7% objective response rate (ORR) in patients with Late-line refractory hepatocellular carcinoma (HCC). The data, selected for an oral presentation at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, highlight a potential new benchmark for patients who have exhausted standard therapies.
Landmark Efficacy in a High-Unmet Need Setting
kAmw6A2E@46==F=2C 42C4:?@>2 WwrrX C6>2:?D 2 4C:E:42= 8=@32= 962=E9 492==6?86[ A2CE:4F=2C=J :? r9:?2[ H9:49 244@F?ED 7@C >@C6 E92? @?6\E9:C5 @7 E96 H@C=5VD @G6C g__[___ 2??F2= 562E9D 7C@> E96 5:D62D6] (9:=6 7C@?E=:?6 EC62E>6?ED 92G6 6G@=G65[ @AE:@?D 7@C A2E:6?ED 72:=:?8 D64@?5\=:?6 E96C2AJ 2C6 D42C46[ H:E9 9:DE@C:42= ~##D EJA:42==J 36=@H `bT]k^Am
kAm~C:46==VD C68:DEC2E:@?2= !92D6 x3 qtpr~} DEF5J 492==6?86D E9:D DE2EFD BF@] pD @7 pAC:= b[ a_ae[ 2>@?8 `g 677:424J\6G2=F23=6 A2E:6?ED H:E9 25G2?465[ 962G:=J AC6EC62E65 wrrik^Am
kF= EJA6lQ5:D4Qmk=:m~G6C2== ~## C624965 d_T]k^=:mk=:mpE E96 #64@>>6?565 !92D6 a s@D6 W#!asX[ ~## DFC865 E@ ee]fT[ H:E9 2 5:D62D6 4@?EC@= C2E6 Wsr#X ?62C:?8 h_T]k^=:mk=:msFC23:=:EJ H2D AC@7@F?5i ~?6 A2E:6?E 249:6G65 2 4@>A=6E6 C6DA@?D6 Wr#X =2DE:?8 ac >@?E9D]k^=:mk=:m$276EJ H2D >2?28623=6i }@ :>>F?6 67764E@C 46==\2DD@4:2E65 ?6FC@E@I:4:EJ DJ?5C@>6 Wxrp}$X @C @77\EF>@C E@I:4:EJ H2D @3D6CG65[ H:E9 4JE@<:?6 C6=62D6 DJ?5C@>6 Wr#$X 4@?E2:?65 H:E9:? 4@?EC@==23=6 8C256D]k^=:mk^F=m
kAmkDEC@?8m{@?8\%6C> '2=:52E:@?i uC@> a_a` p$r~ !@DE6C E@ #68:DEC2E:@?2= s2E2k^DEC@?8mk^Am
kAm}@E23=J[ 2D 62C=J 2D a_a`[ ~C:46==VD :?G6DE:82E@C\:?:E:2E65 EC:2= Wxx%X 52E2 7@C ~C:\r`_` H6C6 D6=64E65 7@C 2 A@DE6C AC6D6?E2E:@? 2E p$r~] pE E92E E:>6[ 2 DEC:<:?8 C6DA@?D6 H2D @3D6CG65 :? 2 =2E6\=:?6 wrr A2E:6?E 7@==@H:?8 2 D:?8=6 :?7FD:@?i E96 7:CDE 677:424J 2DD6DD>6?E D9@H65 2 A2CE:2= C6DA@?D6 W!#X[ H:E9 E2C86E =6D:@?D D9C:?<:?8 3J he]`T W7C@> `dd]cd >> E@ e >>X 2?5 2=A92\76E@AC@E6:? Wpu!X =6G6=D A=F>>6E:?8 3J hh]`T W7C@> U8Ejg_[___ ?8^>{ E@ fca ?8^>{X] %96 A2E:6?E 249:6G65 2? @G6C2== DFCG:G2= W~$X @7 ?62C=J E9C66 J62CD]k^Am
k5:G 4=2DDlQ!#}0x>365565pDD6E#676C6?46Q :5lQs:GpDD6E!=246w@=56CfddbQmkAmk2 9C67lQ9EEADi^^>>2]AC?6HDH:C6]4@>^>65:2^ahh`dhe^:>286`]9E>=Q E2C86ElQ03=2?<Q C6=lQ?@7@==@HQmk^2mk^Amk^5:Gm
kAm%96 ?@H\F?G6:=65Â C68:DEC2E:@?2= 4=:?:42= 52E2 7FCE96C G2=:52E6 E96 4=:?:42= G2=F6 @7 ~C:\r`_`[ C6:?7@C4:?8 E96 4@?D:DE6?4J 2?5 C6AC@5F4:3:=:EJ @7 ~C:46==VD 2AAC@249 7C@> 62C=J AC@@7\@7\4@?46AE E@ A:G@E2= EC:2=D]k^Am
kAmkDEC@?8m%649?@=@8J q24<3@?6i pk^DEC@?8m kDEC@?8mQk^DEC@?8mkDEC@?8m%9C66\:?\~?6k^DEC@?8mkDEC@?8mQk^DEC@?8m kDEC@?8mt?8:?6 p55C6DD:?8 $@=:5 %F>@C q2CC:6CDk^DEC@?8mk^Am
kAm~C:\r`_`VD 6I46AE:@?2= A6C7@C>2?46 DE6>D 7C@> ~C:46==VD AC@AC:6E2CJ E649?@=@8J A=2E7@C>D[ DJDE6>2E:42==J 255C6DD:?8 >2;@C 492==6?86D :? rp#\% E96C2AJ 7@C D@=:5 EF>@CDi 2?E:86? 96E6C@86?6:EJ[ :>>F?@DFAAC6DD:G6 EF>@C >:4C@6?G:C@?>6?E W%|tX[ 2?5 >2?F724EFC:?8 677:4:6?4J]k^Am
kAmkDEC@?8m`] ~C:®p3 Wpx\!@H6C65 p?E:3@5J s:D4@G6CJ !=2E7@C>k^DEC@?8mkDEC@?8m）k^DEC@?8mk^Am
kAm%96 ~C:®p3 A=2E7@C> 762EFC6D 2 >2DD:G6 =:3C2CJ 4@>AC:D:?8 FA E@ `_¹¹ 7F==J 9F>2? D4uG 2?5 ?2?@3@5J D6BF6?46D] &E:=:K:?8 2 =:G6\46==\32D65 9:89\E9C@F89AFE D4C66?:?8 DEC2E68J[ E96 A=2E7@C> DA64:7:42==J :56?E:7:6D ?2E:G6 4@?7@C>2E:@?2= 2?E:86?D[ :?4=F5:?8 492==6?8:?8 E2C86ED DF49 2D v!r#D[ E96C63J 2G@:5:?8 E96 72=D6\A@D:E:G6 C:D<D 2DD@4:2E65 H:E9 AFC:7:65 AC@E6:?\32D65 D4C66?:?8] uFCE96C>@C6[ px\2DD:DE65 2=8@C:E9>D 92G6 4@>AC6DD65 E96 2?E:3@5J 5:D4@G6CJ 2?5 D4C66?:?8 4J4=6 7C@> 2 EC25:E:@?2= `a >@?E9D E@ ;FDE b >@?E9D[ D:8?:7:42?E=J 6?92?4:?8 3@E9 677:4:6?4J 2?5 BF2=:EJ] %96 C6DF=E:?8 9:89\DA64:7:4:EJ[ @AE:>2==J 277:?6 v!rb 2?E:3@5J D6BF6?46 6BF:AD ~C:\r`_` H:E9 2 C@3FDE D276EJ AC@7:=6[ 67764E:G6=J >:?:>:K:?8 E96 C:D< @7 @77\EF>@C E@I:4:EJ]k^Am
kAmkDEC@?8ma] ~C:®pC>@C:?8 W$ECF4EFC6\t?92?465 r6== !=2E7@C>Xk^DEC@?8mk^Am
kAm%96 ~C:®pC>@C:?8 A=2E7@C> :?4@CA@C2E6D 4FDE@>:K65 Q2C>@C:?8Q 6=6>6?ED 56D:8?65 E@ >@5F=2E6 % 46== >6E23@=:4 A2E9H2JD 2?5 D:8?2= EC2?D5F4E:@? 32D65 @? E96 DA64:7:4 EF>@C >:4C@6?G:C@?>6?E W%|tX] %9:D 6?8:?66C:?8 DEC2E68J 6?C:496D J@F?8[ DE6>\=:<6 >6>@CJ % 46== DF3D6ED W%D4>X[ D:8?:7:42?E=J 6?92?4:?8 E96 :? G:G@ A6CD:DE6?46 @7 ~C:\r`_`] qJ C6>@56=:?8 E96 =@42= :>>F?6 >:4C@6?G:C@?>6?E[ E96 A=2E7@C> 67764E:G6=J C6G6CD6D :>>F?@DFAAC6DD:@?[ 4@?G6CE:?8 Q4@=5 EF>@CDQ :?E@ Q9@E EF>@CD[Q E96C63J AC@>@E:?8 E96 :?7:=EC2E:@? 2?5 24E:G2E:@? @7 67764E@C % 46==D] %9:D 2AAC@249 @G6C4@>6D E96 5F2= 3@EE=6?64<D @7 E96 :>>F?@DFAAC6DD:G6 %|t 2?5 % 46== 6I92FDE:@? :? D@=:5 EF>@CD[ 6?DFC:?8 5FC23=6[ =@?8\E6C> C6DA@?D6D] p55:E:@?2==J[ E96 A=2E7@C> :?E68C2E6D =@8:4\82E:?8 DEC2E68:6D—:?4=F5:?8 V~#V 82E:?8 E@ AC6G6?E 2?E:86? 6D42A6 2?5 Vp}sV 82E:?8 E@ :>AC@G6 E2C86E:?8 AC64:D:@?—H9:49 4@==64E:G6=J @AE:>:K6 E96 E96C2A6FE:4 :?56I @7 E96 AC@5F4E]k^Am
kAmkDEC@?8mb] ~C:®~?v@i u=6I:3=6 |2?F724EFC:?8 !=2E7@C> Wr=2DD:4 ^ #2A:5 ^ x? ':G@Xk^DEC@?8mk^Am
kAmqF:=E @? 2 Q"F2=:EJ 3J s6D:8?Q W"3sX A9:=@D@A9J[ E9:D A=2E7@C> :?4=F56D AC@AC:6E2CJ >2?F724EFC:?8 E649?@=@8:6D] %96 C2A:5 >2?F724EFC:?8 AC@46DD C65F46DÂ 6I G:G@Â 4F=EFC6 E:>6 E@ ;FDE b 52JD[ D:8?:7:42?E=J :>AC@G:?8 AC@5F4E:G:EJ 2?5 =@H6C:?8 4@DE @7 8@@5D Wr~v$X] xE 6?DFC6D 7:?2= AC@5F4E 46== G:23:=:EJ 4@?D:DE6?E=J 23@G6 hdT[ 2?5 4@>AC6DD6D E96 G6:?\E@\G6:? E:>6 E@ H:E9:? `d 52JD] |@C6@G6C[ E96 A=2E7@C>VDÂ :? G:G@Â rp#\% AC@5F4E 56D:8? 2?5 AC@46DD 42A23:=:E:6D @A6? 3C@256C 7FEFC6 2AA=:42E:@?D 7@C rp#\% E96C2AJ] %9:D :?E68C2E65 >2?F724EFC:?8 2AAC@249 6?23=6D D42=23=6[ 4@DE\67764E:G6 AC@5F4E:@? H9:=6 >2:?E2:?:?8 AC@5F4E BF2=:EJ 2?5 A2E:6?E 2446DD]k^Am
kAmkDEC@?8mtI64FE:G6 ~FE=@@<k^DEC@?8mk^Am
kAmQ$64FC:?8 2 E9:C5 p$r~ @C2= AC6D6?E2E:@? G2=:52E6D @FC :?E68C2E65 A=2E7@C> DEC2E68J[Q D2:5 sC] w6=6? *2?8[ r@\u@F?56C 2?5 rt~ @7 ~C:46==] Q(6 2C6 2446=6C2E:?8 E96 A:G@E2= !92D6 xx 56G6=@A>6?E E@ 3C:?8 E9:D E96C2AJ E@ >2C<6E] (6 2C6 2=D@ 24E:G6=J D66<:?8 8=@32= A2CE?6CD9:AD E@ 6IA2?5 E96 C6249 @7 @FC E649?@=@8J 2?5 56=:G6C 9@A6 E@ A2E:6?ED H@C=5H:56]Qk^Am
kAmkDEC@?8mp3@FE ~C:46== %96C2A6FE:4Dk^DEC@?8mk^Am
kAm~C:46== :D 2 4=:?:42=\DE286 8=@32= 3:@E649?@=@8J 4@>A2?J 565:42E65 E@ 364@>:?8 2 A:@?66C :? EF>@C :>>F?@E96C2AJ] u@4FD65 @? D@=G:?8 F?>6E >65:42= ?665D :? @?4@=@8J 2?5 :>>F?@=@8J[ 3J A@H6C:?8 2 AC@AC:6E2CJ E649?@=@8J EC:25i ~C:®p3 W2?E:3@5J 5:D4@G6CJX[ ~C:®pC>@C:?8 W%\46== 6?92?46>6?EX[ 2?5 ~?v@ r|r WC2A:5 >2?F724EFC:?8X[ ~C:46== 92D DF446DD7F==J 6DE23=:D965 2 C@3FDE A:A6=:?6 E2C86E:?8 3@E9 D@=:5 2?5 96>2E@=@8:42= EF>@CD] %96 4@>A2?JVD 4=:?:42= EC2?D=2E:@? 42A23:=:E:6D 92G6 366? C64@8?:K65 8=@32==J[ H:E9 >F=E:A=6 52E2 C625@FED D6=64E65 7@C @C2= AC6D6?E2E:@?D 2E >2;@C :?E6C?2E:@?2= 4@?76C6?46D :?4=F5:?8 p$r~ 2?5 twp[ 2?5 AF3=:D965 :? E@A\E:6C ;@FC?2=D DF49 2D %96 {2?46E w26>2E@=@8J] u@C >@C6 :?7@C>2E:@?[ G:D:E k2 9C67lQ9EEADi^^HHH]@C:46==]4@>^Q E2C86ElQ03=2?<Q C6=lQ?@7@==@HQmHHH]@C:46==]4@>k^2m]k^Am
kAmkDEC@?8mu@CH2C5\{@@<:?8 $E2E6>6?EDk^DEC@?8mk^Am
kAm%9:D AC6DD C6=62D6 4@?E2:?D Q7@CH2C5\=@@<:?8 DE2E6>6?EDQ H9:49 2C6 ?@E 9:DE@C:42= 724ED[ 3FE :?DE625 2C6 AC65:4E:@?D 23@FE 7FEFC6 6G6?ED 32D65 @? E96 36=:67D 2D H6== 2D 2DDF>AE:@?D >256 3J 2?5 :?7@C>2E:@? 4FCC6?E=J 2G2:=23=6 E@ E96 >2?286>6?E @7 ~C:46== %96C2A6FE:4D w@=5:?8D {:>:E65 WQE96 r@>A2?JQ @C Q~C:46==QX] %96 H@C5D Q2?E:4:A2E6[Q Q36=:6G6[Q Q4@?E:?F6[Q Q4@F=5[Q Q6DE:>2E6[Q Q6IA64E[Q Q:?E6?5[Q Q>2J[Q QA=2?[Q QA@E6?E:2=[Q QAC65:4E[Q QAC@;64E[Q QD9@F=5[Q QE2C86E[Q QH:==[Q QH@F=5Q 2?5 D:>:=2C 6IAC6DD:@?D 2C6 :?E6?565 E@ :56?E:7J 7@CH2C5\=@@<:?8 DE2E6>6?ED[ 2=E9@F89 ?@E 2== 7@CH2C5\=@@<:?8 DE2E6>6?ED 4@?E2:? E96D6 :56?E:7J:?8 H@C5D] $F49 7@CH2C5\=@@<:?8 DE2E6>6?ED :?G@=G6 <?@H? 2?5 F?<?@H? C:D<D[ F?46CE2:?E:6D 2?5 @E96C :>A@CE2?E 724E@CD E92E 4@F=5 42FD6 E96 24EF2= C6DF=ED[ A6C7@C>2?46 @C 249:6G6>6?ED @7 E96 r@>A2?J[ @C :?5FDECJ C6DF=ED[ E@ 5:776C >2E6C:2==J 7C@> 2?J 7FEFC6 C6DF=ED[ A6C7@C>2?46 @C 249:6G6>6?E :>A=:65 3J DF49 7@CH2C5\=@@<:?8 DE2E6>6?ED] p?J 7@CH2C5\=@@<:?8 DE2E6>6?ED 4@?E2:?65 :? E9:D AC6DD C6=62D6 DA62< @?=J 2D @7 E96 52E6 @7 E9:D AC6DD C6=62D6] %96 r@>A2?J 2DDF>6D ?@ @3=:82E:@? E@ FA52E6 2?J 7@CH2C5\=@@<:?8 DE2E6>6?E[ H96E96C 2D 2 C6DF=E @7 ?6H :?7@C>2E:@?[ 7FEFC6 6G6?ED @C @E96CH:D6]k^Am
k5:G 4=2DDlQ!#}0x>365565pDD6E#676C6?46Q :5lQs:GpDD6E!=246w@=56C_Qmk^5:Gm
kA :5lQ!&#{Qmk:>8 E:E=6lQr:D:@?Q H:5E9lQ`aQ 96:89ElQ`aQ 2=ElQr:D:@?Q DC4lQ9EEADi^^6586]AC?6HDH:C6]4@>^4^:>8^72G:4@?]A?8nD?lr}fa`a`U2>AjD5la_ae\_d\b`Q ^m ':6H @C:8:?2= 4@?E6?E E@ 5@H?=@25 >F=E:>65:2ik2 :5lQ!#}&#{Q C6=lQ?@7@==@HQ 9C67lQ9EEADi^^HHH]AC?6HDH:C6]4@>^?6HD\C6=62D6D^2D4@\a_ae\\@C:46==D\8A4b\42C\E\@C:\4`_`\9:ED\ee\f\@CC\:?\=2E6\=:?6\944\D:8?2=:?8\36DE\:?\4=2DD\A@E6?E:2=\b_afgeebg]9E>=Q E2C86ElQ03=2?<Qm9EEADi^^HHH]AC?6HDH:C6]4@>^?6HD\C6=62D6D^2D4@\a_ae\\@C:46==D\8A4b\42C\E\@C:\4`_`\9:ED\ee\f\@CC\:?\=2E6\=:?6\944\D:8?2=:?8\36DE\:?\4=2DD\A@E6?E:2=\b_afgeebg]9E>=k^2mk^Am
kAm$~&#rt ~C:46== %96C2A6FE:4D w@=5:?8D {:>:E65k^Am
kAmk:>8 2=ElQQ DC4lQ9EEADi^^CE]AC?6HDH:C6]4@>^CE]8:7n}6HDxE6>x5lr}fa`a`U2>Aj%C2?D>:DD:@?0x5la_ae_db`aabf!#0}t($0&$!#00000r}fa`a`U2>Ajs2E6x5la_ae_db`Q DEJ=6lQ3@C56Ci_AIj H:5E9i`AIj 96:89Ei`AIjQ ^mk^Am
